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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1999 1
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2010 1
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2015 4
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2022 6
2023 3
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41 results

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circKL inhibits the growth and metastasis of kidney cancer by sponging miR-182-5p and upregulating FBXW7.
Cao J, Yu U, Li L, Yuan X, Chen S, Xu H, Yi M, Liu S. Cao J, et al. Oncol Rep. 2022 Apr;47(4):75. doi: 10.3892/or.2022.8286. Epub 2022 Feb 18. Oncol Rep. 2022. PMID: 35179220 Free PMC article.
Western blot assays confirmed that overexpression of circKL significantly increased the protein level of F-box and WD repeat domain containing 7 (FBXW7). All results suggested that circKL suppressed the growth and migration of kidney cancer by sponging microRNA (miR …
Western blot assays confirmed that overexpression of circKL significantly increased the protein level of F-box and WD repeat domain containi …
CDK1/FBXW7 facilitates degradation and ubiquitination of MLST8 to inhibit progression of renal cell carcinoma.
Zhang E, Chen S, Tang H, Fei C, Yuan Z, Mu X, Qin Y, Liu H, Fan Y, Tan M, Wang X. Zhang E, et al. Cancer Sci. 2022 Jan;113(1):91-108. doi: 10.1111/cas.15188. Epub 2021 Nov 16. Cancer Sci. 2022. PMID: 34741373 Free PMC article.
MLST8 can be degraded and ubiquitinated by tumor suppressor FBXW7. FBXW7 recognizes a consensus motif (T/S) PXX (S/T/D/E) of MLST8 and triggers MLST8 degradation via the ubiquitin-proteasome pathway. ...Furthermore, the MLST8 and FBXW7 proteins are negatively …
MLST8 can be degraded and ubiquitinated by tumor suppressor FBXW7. FBXW7 recognizes a consensus motif (T/S) PXX (S/T/D/E) of M …
Upregulation of FBXW7 Suppresses Renal Cancer Metastasis and Epithelial Mesenchymal Transition.
Cai Y, Zhang M, Qiu X, Wang B, Fu Y, Zeng J, Bai J, Yang G. Cai Y, et al. Dis Markers. 2017;2017:8276939. doi: 10.1155/2017/8276939. Epub 2017 Sep 30. Dis Markers. 2017. PMID: 29097832 Free PMC article.
Upregulation of FBXW7 was performed in vitro on RCC cells using the lentivirus covering coding region FBXW7 cDNA sequence, and functional tests were performed to verify FBXW7 overexpression on migration and invasion of RCC cells. ...CONCLUSION: Our findings d …
Upregulation of FBXW7 was performed in vitro on RCC cells using the lentivirus covering coding region FBXW7 cDNA sequence, and …
FBXW7 overexpression suppresses renal cancer cell proliferation and induces apoptosis.
Fu Y, Lin Y, Yang Z, Yang G, Li G, Liu Y, Tan X, Huang Y, Wu X, Wang Y, Xiong H, Zhang M, Fang L, Ge Y, Zeng J, Cai Y, Bai J, Wu S. Fu Y, et al. Med Oncol. 2015 Aug;32(8):215. doi: 10.1007/s12032-015-0656-1. Epub 2015 Jul 11. Med Oncol. 2015. PMID: 26163148
FBXW7 high-expression patients have overall better prognosis than low-expression patients (P < 0.001). ...By Western blot analysis, expression of cell proliferation-activating protein c-Myc and c-Jun is downregulated in FBXW7 high-expression RCC compared with neg …
FBXW7 high-expression patients have overall better prognosis than low-expression patients (P < 0.001). ...By Western blot analysis …
Sp1-like protein KLF13 acts as a negative feedback regulator of TGF-β signaling and fibrosis.
Yang S, Xiang J, Ma C, Yang G, Wang X, Liu H, Fan G, Kang L, Liang Z. Yang S, et al. Cell Rep. 2023 Apr 25;42(4):112367. doi: 10.1016/j.celrep.2023.112367. Epub 2023 Apr 7. Cell Rep. 2023. PMID: 37029927 Free article.
Transforming growth factor beta (TGF-beta) is the primary factor that drives fibrosis in most forms of chronic kidney disease. The aim of this study was to identify endogenous regulators of TGF-beta signaling and fibrosis. ...However, persistent activation of TGF-beta sign …
Transforming growth factor beta (TGF-beta) is the primary factor that drives fibrosis in most forms of chronic kidney disease. The ai …
RASA1 inhibits the progression of renal cell carcinoma by decreasing the expression of miR-223-3p and promoting the expression of FBXW7.
Zhang RL, Aimudula A, Dai JH, Bao YX. Zhang RL, et al. Biosci Rep. 2020 Jul 31;40(7):BSR20194143. doi: 10.1042/BSR20194143. Biosci Rep. 2020. PMID: 32588875 Free PMC article. Retracted.
Then, the targeted correlations of miR-223-3p with FBXW7 and RASA1 were verified via a dual-luciferase reporter gene assay. ...Additionally, FBXW7 and RASA1 inhibited cell proliferation but facilitated the population of RCC cells in the G0/G1 phase. ...
Then, the targeted correlations of miR-223-3p with FBXW7 and RASA1 were verified via a dual-luciferase reporter gene assay. ...Additi …
Germline (epi)genetics reveals high predisposition in females: a 5-year, nationwide, prospective Wilms tumour cohort.
Stoltze UK, Hildonen M, Hansen TVO, Foss-Skiftesvik J, Byrjalsen A, Lundsgaard M, Pignata L, Grønskov K, Tumer Z, Schmiegelow K, Brok JS, Wadt KAW. Stoltze UK, et al. J Med Genet. 2023 Sep;60(9):842-849. doi: 10.1136/jmg-2022-108982. Epub 2023 Apr 5. J Med Genet. 2023. PMID: 37019617 Free PMC article.
RESULTS: Of 24 patients (58% female), 3 (13%, all female) harboured pathogenic germline variants in WT risk genes (FBXW7, WT1 and REST). Only one patient had a family history of WT (3 cases), segregating with the REST variant. ...We observed more patients with macrosomia ( …
RESULTS: Of 24 patients (58% female), 3 (13%, all female) harboured pathogenic germline variants in WT risk genes (FBXW7, WT1 and RES …
Site-specific phosphorylation of Fbxw7 by Cdk5/p25 and its resulting decreased stability are linked to glutamate-induced excitotoxicity.
Ko YU, Kim C, Lee J, Kim D, Kim Y, Yun N, Oh YJ. Ko YU, et al. Cell Death Dis. 2019 Aug 2;10(8):579. doi: 10.1038/s41419-019-1818-4. Cell Death Dis. 2019. PMID: 31371703 Free PMC article.
This phosphorylation was eventually linked to decreased stability of Fbxw7. Using a culture model of cortical neurons challenged with glutamate, we confirmed that decreased stability of Fbxw7 was indeed Cdk5-dependent. Furthermore, diminished levels of Fbxw7 …
This phosphorylation was eventually linked to decreased stability of Fbxw7. Using a culture model of cortical neurons challenged with …
Subtype-specific FBXW7 mutation and MYCN copy number gain in Wilms' tumor.
Williams RD, Al-Saadi R, Chagtai T, Popov S, Messahel B, Sebire N, Gessler M, Wegert J, Graf N, Leuschner I, Hubank M, Jones C, Vujanic G, Pritchard-Jones K; Children's Cancer and Leukaemia Group; SIOP Wilms' Tumour Biology Group. Williams RD, et al. Clin Cancer Res. 2010 Apr 1;16(7):2036-45. doi: 10.1158/1078-0432.CCR-09-2890. Epub 2010 Mar 23. Clin Cancer Res. 2010. PMID: 20332316 Free PMC article.
Strikingly, 3 of 14 (21%) of tumors with epithelial type histology after neoadjuvant chemotherapy had FBXW7 aberrations, whereas a fourth WT patient had germline mutations in both FBXW7 and WT1. We also showed that MYCN copy number gain, detected in 9 of 104 (8.7%) …
Strikingly, 3 of 14 (21%) of tumors with epithelial type histology after neoadjuvant chemotherapy had FBXW7 aberrations, whereas a fo …
Genome and transcriptome profiling of FBXW family in human prostate cancer.
Lan R, Jin B, Liu YZ, Zhang K, Niu T, You Z. Lan R, et al. Am J Clin Exp Urol. 2020 Aug 15;8(4):116-128. eCollection 2020. Am J Clin Exp Urol. 2020. PMID: 32929407 Free PMC article.
In contrast, FBXW7 mRNA expression was significantly increased in cholangiocarcinoma, colon adenocarcinoma, kidney renal clear cell carcinoma, kidney renal papillary cell carcinoma, liver hepatocellular carcinoma, lung adenocarcinoma, pheochromocytoma and par …
In contrast, FBXW7 mRNA expression was significantly increased in cholangiocarcinoma, colon adenocarcinoma, kidney renal clear …
41 results